Nucleation and Crystal Growth of Hemoglobins: The Case of HbC
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Hemoglobin (Hb) crystallization is of significance both in vivo and in vitro. Hb crystals form in red blood cells (RBCs), as occurs in the case of patients expressing βC -globin (β6 Glu→Lys). In vitro, high-resolution structural determination by crystallographic methods requires the growth of Hb crystals to approx ∼1 mm in diameter, which may be induced by a variety of precipitants.
