Characterization of Nanomaterials for Toxicological Studies

The scientific community, regulatory agencies, environmentalists, and most industry representatives all agree that more effort is required to ensure the responsible and safe development of new nanotechnologies. Characterizing nanomaterials is a key aspect in this effort. There is no universally agreed upon minimum set of characteristics although certain common properties are included in most recommendations. Therefore, characterization becomes more like a puzzle put together with various measurements rather than a single straightforward analytical measurement. In this chapter, we emphasize and illustrate the important elements of nanoparticle characterization with a systematic approach to physicochemical characterization. We start with an overview describing the properties that are most significant to toxicological testing along with suggested methods for characterizing an as-received nanomaterial and then specifically address the measurement of size, surface properties, and imaging.