8 Determination of Plasma Homocysteine
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A number of epidemiological and clinical studies have linked elevated plasma homocysteine (Hcy) to atherosclerotic vascular disease affecting coronary, carotid, and peripheral vessels. Plasma Hcy can be considered a marker of methionine metabolic efficiency, mainly affected by dietary intake of vitamins, especially folate, vitamin B6 , and B12 , as well as by genetic mutations of key metabolic enzymes and renal elimination.
