Animal Models for Tumor Localization

Many factors influence the uptake of radiolabeled monoclonal antibodies (mAbs) in tumors. Some are dependent on the antibody, such as affinity, intact immunoglobulin or fragment, route of administration, choice of radio isotope, or method of labeling. Others depend on properties of the tumor, such as site, size, vasculature, and antigen density on the tumor cell surface. Animal models for studying these parameters are usually based on mice or rats bearing transplanted tumors. In this chapter, various tumor model systems will be described with some discussion of what data can be obtained using them.