CD69分子
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CD69 分子
CD69
常用单克隆抗体或代号： Leu23;(VEA,AIM)
主要表达细胞： Ta,Ba,Mac,NK,Pt [NK]
分子质量(kDa)和结构： 34,28(同源二聚体,C- lectin SF)
功 能： 活化诱导分子,参与信号转导,Eo凋亡,参与TCRd g 溶细胞功能
CD69
Aka activation inducer molecule (AIM), early activation antigen (EA-1)
Earliest inducible cell surface glycoprotein acquired during lymphoid activation
Involved in early events of T cell, NK cell, monocyte and platelet activation
Associated with Th-1 T cell differentiation and associated cytokines (IL-2, TNF-alpha, interferon-gamma), Hum Path 2002;33:330
Highly expressed on T cells from inflammatory infiltrates of rheumatoid arthritis, viral hepatitis, autoimmune thyroid disorders;
Positive staining (normal): activated T cells, B cells, NK cells, neutrophils, eosinophils, epidermal Langerhans cells
Positive staining (disease): T cell lymphomas (angioimmunoblastic, Lennert’s, mycosis fungoides/Sezary syndrome)
Negative staining: anaplastic large cell lymphoma
Micro images (Hum Path subscribers): A-tonsil, B-peripheral T cell lymphoma NOS, C-anaplastic large cell lymphoma (H&E, frozen, paraffin)
