CD86分子
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CD86 分子
CD86
常用单克隆抗体或代号： FUN- 1,BU63,GR65;(B7- 2)
主要表达细胞： Ba,M [B]
分子质量(kDa)和结构： gp80(IgSF)
功 能： CD28、CTLA- 4配体,提供T细胞共刺激信号
CD86
Summary: Costimulates IL-2 production and T cell proliferation
Aka B7-2
Ligand for CD28 (CD80 also binds CD28), CD152 (CTLA4)
Induction of an immune response requires T cells to receive 2 sets of signals from antigen presenting cells. The first is delivered through the T-cell receptor complex, while the second is provided by the B-cell activation antigens B7-1, or CD80 and B7-2, or CD86 by interaction with the T-cell surface molecules CD28 and CTLA4
Positive staining (normal): interdigitating dendritic cells in T zones of secondary lymphoid organs, Langerhans cells, peripheral blood dendritic cells, memory B cells, germinal center B cells, monocytes (higher levels after g-IFN), endothelial cells, activated T cells
Reference: GeneCards
