Migraine Models
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Migraine is a high prevalence disorder which affects a significant proportion of the general population, especially women
during their central and more productive time of the life, thus causing severe disability. The genetic basis of the disease
is unknown and the mechanism is poorly understood. The possibility that following a perturbation in the central nervous system,
and particularly in the brainstem, trigeminal neurons become hyperexcitable and produce an uncontrolled release of sensory
neuropeptides which eventually results in arterial vasodilatation and neuronal sensitization, has been gaining credit from
studies in experimental animals and humans. In particular, experimental and clinical data with antagonists of the calcitonin
gene-related peptide (CGRP) propose this molecule and its receptor as a major target for migraine treatment.