CD52分子
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CD52 分子
常用单克隆抗体或代号： YTH66.9;(Campath- 1)
主要表达细胞： Leu,Eo [NL]
分子质量(kDa)和结构： gp25- 29
功 能： 补体介导溶解作用的靶分子
Aka Campath-1
CD52 antibodies are lytic for target cells, both with human complement and via antibody dependent cellular cytotoxicity
CD52 antibodies used for long-term depletion of lymphocytes in vivo, in trials for CLL and as immunosuppressant; patients have higher risk for opportunitistic infections
Positive staining (normal): thymocytes, lymphocytes, monocytes/macrophages, eosinophils, epithelial cells lining the male reproductive tract
Positive staining (disease): most lymphoid malignancies (variable levels),
Negative staining: lymphocytes from patients with PNH, neutrophils (weaker than eosinophils)
