CD52分子

Aka Campath-1

CD52 antibodies are lytic for target cells, both with human complement and via antibody dependent cellular cytotoxicity

CD52 antibodies used for long-term depletion of lymphocytes in vivo, in trials for CLL and as immunosuppressant; patients have higher risk for opportunitistic infections

Positive staining (normal): thymocytes, lymphocytes, monocytes/macrophages, eosinophils, epithelial cells lining the male reproductive tract

Positive staining (disease): most lymphoid malignancies (variable levels),

Negative staining: lymphocytes from patients with PNH, neutrophils (weaker than eosinophils)