【求助】ERK1/2，在线等

MER
ERK
跟MAPK什么联系
是ERK/MAPK信号通路还是还是ERK1/2/MAPK通路
1/2是什么意思，

google了一下，“1/2”是指ERK-1/ERK-2。

The extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), also called p44 and p42 MAP kinases, are members of the Mitogen Activated Protein Kinase (MAPK) family of proteins found in all eukaryotes. Because the 44 kDa ERK1 and the 42 kDa ERK2 are highly homologous and both function in the same protein kinase cascade, the two proteins are often referred to collectively as ERK1/2 or p44/p42 MAP kinase. The ERK1/2 signaling cascade has been shown to be a critical regulator of cell differentiation, cell physiology and neuronal function. Aberrant control of ERK1/2 activity has been implicated in a variety of pathological conditions, including cancer and autoimmune diseases, and efficient study methods are in demand.

Thanks.....
还是版主胸怀宽广愿意理我种ruozhi问题

我又掌握了一条知识了，谢谢帮助，您这是怎找到的，关键是我不会找，只有求救了

ERK是MAPK的一种，MAPK可以分为三种：ERK、JNK、p38MAPK，其中ERK又有ERK-1和ERK-2两种亚型，分子量分别为44和42KD。

MAPK很复杂，好像不只三种。

The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of various cellular processes such as proliferation, differentiation, development, learning, survival and, under some conditions, also apoptosis. The ability of this cascade to regulate so many distinct, and even opposing, cellular processes, raises the question of signaling specificity determination by this cascade.
Four distinct MAPK cascades (ERK, JNK, p38 and BMK) have been elucidated, although their number is likely to increase, due to the identification of novel MAPKs that are not specified to any known pathway.
推荐阅读：
1.Shaul YD, Seger R. Biochimica et Biophysica Acta 2007,1773:1213–1226
2. Murphy LO and Blenis J. TRENDS in Biochemical Sciences 2006,31:268–275

The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of various cellular processes such as proliferation, differentiation, development, learning, survival and, under some conditions, also apoptosis. The ability of this cascade to regulate so many distinct, and even opposing, cellular processes, raises the question of signaling specificity determination by this cascade.
Four distinct MAPK cascades (ERK, JNK, p38 and BMK) have been elucidated, although their number is likely to increase, due to the identification of novel MAPKs that are not specified to any known pathway.
推荐阅读：Y.D. Shaul, R. Seger / Biochimica et Biophysica Acta 1773 (2007) 1213–1226

ERK1/2对细胞周期起负调控作用，但我做的实验结果是，药物导致细胞增殖减慢，而western blot结果却显示ERK1/2表达却显著增加，不知对该结果如何解释，请教高手帮忙分析。

MAPK 包括ERK JNK P38MAPK ERK ERK是其中一条经典通路