丁香实验_LOGO
登录
提问
我要登录
|免费注册
点赞
收藏
wx-share
分享

NKT and Tolerance

互联网

506
NKT cells are innate-like αβ T cells that are conserved between humans and mice. They are distinct from conventional T cells as they recognize lipid antigens presented by the CD1d molecule. Most NKT cells expressed a highly restricted TCR repertoire and can be activated by α-galactosylceramide (α-GalCer) and detected by α-GalCer-loaded-CD1d tetramers. Upon activation, NKT cells respond in few hours by producing cytokines and stimulating many other cells of the innate and adaptive immune system. Over the last decade, many studies have analyzed the regulatory role of NKT cells that can either suppress or exacerbate immune functions. This chapter describes the tools and techniques required to study in vivo and in vitro the regulatory role of NKT cells in mouse as well as from human blood.
提问
扫一扫
丁香实验小程序二维码
实验小助手
丁香实验公众号二维码
扫码领资料
反馈
TOP
打开小程序