Statistical Methods for Proteomics

What is Proteomics? The term proteome denotes the PROTEin complement expressed by a genOME or tissue. While the genome is an invariant feature of an organism, the proteome depends on its developmental stage, the tissue considered, and environmental/experimental conditions. There are more proteins in a proteome than genes in genome (which is particularly true for eukaryotes). For instance, there are several ways to splice a gene to generate messenger ribonucleic acid (mRNA). Furthermore, proteins can undergo posttranslational alterations such as truncation at the amino- (N)- and carboxy (C)-terminus and addition of saccharide or phosphate groups.