Assessment of T-Cell Function in the Aged
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Certain immunological activities, particularly cell-mediated immunity, decline with advancing age. Gaining insight into the underlying mechanism(s) is complicated by the fact that human T-cells comprise several functionally and phenotypically distinct populations and subpopulations. Proliferative studies designed to identify differences between old and young subjects that are based entirely on unfractionated peripheral blood lymphocytes (PBLs) or pan T-cell responses run the risk, therefore, of missing subtle but perhaps crucial changes in a particular T-cell type.
