CD71分子
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CD71 分子
CD71
常用单克隆抗体或代号： OKT9;(TfR)
主要表达细胞： Mac,增殖细胞 [NL]
分子质量(kDa)和结构： p95(同源二聚体)
功 能：结合白细胞生长
CD71
Aka transferrin receptor
Present on actively proliferating cells; essential for iron transport into proliferating cells (benign and malignant)
Ferrotransferrin binds CD71 at neutral pH, is internalized to an acidic endosomal compartment
Iron-free apotransferrin remains bound to CD71 at pH 5, is returned to cell surface, where pH rises to 7.4.
At neutral pH, apotransferrin loses affinity for receptor, is released into circulation, allowing a new cycle to begin
Positive staining (normal): all proliferating cells plus iron requiring cells: reticulocytes, erythroid precursors, capillary endothelium in brain
Positive staining (disease): AML M6, primary effusion lymphoma
