G Proteins in the Etiology and Treatment of Mental Disorders
互联网
722
Given their ubiquitous and crucial role in the integration and amplification of signal transduction pathways, it is not surprising that anomalies in the expression and/or function of various G proteins has been implicated in a multitude of pathophysiological states: pseudohypoparathyroidism (PsHP), heart failure, endocrine tumors, McCune-Albright syndrome, diabetes, alcoholism, schizophrenia, major valve prolapse, chronic cocaine or opiate ingestion, aging, hypo- or hyperthyroidism, and adrenalectomy or corticosteroid medication (Horn and Bilezkian, 1990 ; Hoffman and Tabakoff, 1990 ; Nestler et al, 1990 ; Kerwin and Beats, 1990 ; Dewas et al., 1990 ; Weinstein et al., 1991 ; Davies et al., 1991 ; Nomura et al., 1991 ; Paulssen et al., 1992 ).
