Radiation Hybrid Mapping With BAC Ends

Recent advances in the Human Genome Project have opened the door to new approaches in biologic research. The availability of the human draft sequence (1 ) now offers the tool for sequence-based genetic analyses on a genomewide level. However, owing to the fragmented and incomplete nature of the draft version currently available, work is focusing on ordering and orienting the individual sequence segments relative to each other to unambiguously place them within the sequence of a single, unique chromosome.