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Animal Models of Mental Retardation

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Children with mental retardation typically show a general developmental delay, whereas in specific developmental disorders, there is a delay in a specific area of behavior, such as reading or speech. According to DSMIII (American Psychiatric Association, 1980,1987), the diagnostic criteria for mental retardation include:
1. 
Significantly subaverage general intellectual functioning, i.e., an IQ of 70 or below on an individually administered IQ test.
2. 
Concurrent deficits or impairments in adaptive functioning, i.e., an individual’s effectiveness in meeting standard expectations in a range of areas, such as social skills and responsibility, communication, daily coping, personal independence, and self-sufficiency.
3. 
An onset before the age of 18, i.e., the mental retardation is manifested during the developmental period.
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