Determination of Gene Function by Homologous Recombination Using Embryonic Stem Cells and Knockout Mice
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A decade ago the first alteration of a gene using embryonic stem (ES) cells was performed in the mouse (1 ). Since then ES cells have become a powerful tool to generate mutant mice for the analysis of gene function. These mutant mice (also called knockout mice) have provided new insights into normal and pathologic development to improve our knowledge and open new avenues into diagnostic and therapeutic fields.
