丁香实验_LOGO
登录
提问
我要登录
|免费注册
点赞
收藏
wx-share
分享

Induction of Cellular Senescence by Oncogenic RAS

互联网

501
Cellular senescence is a state of permanent cell cycle arrest, which has been shown to prevent neoplastic transformation. Oncogenes are pro-proliferative genes that promote survival and proliferation of cancer cells. Paradoxically, introduction of an activated oncogene leads to activation of a state similar to cellular senescence, which is referred to as oncogene-induced senescence. Studies have shown that oncogene-induced senescence function as a barrier to neoplastic transformation. Here, we describe a protocol for inducing cellular senescence by oncogenic RAS in primary human fibroblast. The approach that we describe here is of general utility and can be applied to study senescence induction by other defined genetic elements, for example, other activated oncogenes.
提问
扫一扫
丁香实验小程序二维码
实验小助手
丁香实验公众号二维码
扫码领资料
反馈
TOP
打开小程序