Natural Products or Not How to Screen for Natural Products in the Emerging HTS Paradigm
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Natural products are undeniably the best source for diversity in chemotype for the discovery of novel therapeutics. One-third of the top selling drugs in the world are natural products or their derivatives (Fig. 1 ). Roughly 60% of the antitumor and anti-infective agents that are available commercially or were in latestage clinical development from 1989–1995 are of natural products origin ( 1 , 2 ).
Fig. 1. 1999 Top 25 Prescription Drugs: Schematic representation of 1999’s earnings for the 25 top selling prescription drugs, in billions of dollars.
