Apoptosis and Ischemia in the Central Nervous System
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Our understanding of apoptosis and programmed cell death has rapidly evolved over the last decade. As originally conceived, apoptosis was a purely morphological phenomena based on the appearance of membrane blebbing (apoptotic bodies) and nuclear changes, including chromatin condensation and DNA fragmentation. Likewise, programmed cell death was a developmental definition describing the physiologically appropriate “programmed” death of cells during developmental modeling and morphogenesis.
