CD63分子
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CD63 分子
CD63
常用单克隆抗体或代号： RUU- SP2.28,CLB
主要表达细胞： Pt,M,Mac,(G,T,B) [Pt]
分子质量(kDa)和结构： gp53,血小板颗粒蛋白(TM4- SF)
功 能： 血小板活化,中性粒细胞- 活化内皮细胞粘附
CD63
Aka lysosomal-membrane-associated glycoprotein 3, LAMP-3, melanoma associated antigen, NKI-C3
Intracellular lysosomal/endosomal/granule protein, in Weibel-Palade bodies of vascular endothelium
Marker of platelet activation (transported to surface after activation)
Associated with early stages of melanoma progression
Positive staining (normal): activated platelets, macrophages, fibroblasts, osteoclasts, endothelium, smooth muscle, neural tissue (brain white matter and peripheral nerves), synovial lining cells
Positive staining (tumors): melanoma
