Leukotrienes, Lipoxins, and Hydroxyeicosatetraenoic Acids
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Extravasation of neutrophils is an early and critical event during an acute inflammatory response. The process of emigration of leukocytes through the wall of an intact capillary has been described as a “flowing” between endothelial cells (1 ); i.e., the leukocyte reaches the perivascular space by ameboid movements. With an improved understanding of adhesion molecules and the cytoskeleton, the molecular basis for diapedesis is becoming clear. Furthermore, since diverse forms of tissue injury are to an extent neutrophil-dependent; e.g., ischemia-reperfusion injury, immune complex glomerulonephritis, Arthus pleurisy, and flares of colitis; research aimed at the molecular attachments between vascular endothelial cells (2 ) and transendothelial leukocyte migration (3 –6 ) is a promising strategy for discovery of anti-inflammatory medications.
