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In Vitro Model of Human Articular Cartilage Degradation

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Rheumatoid arthritis is characterized by inflamed joints with proliferating synovium and erosion of cartilage and bone. Eventually, loss of articular cartilage leads to a necessity for joint replacement surgery. Elucidation of the mechanisms of cartilage degradation are key to understanding the pathogenesis of rheumatoid arthritis.
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