HER信号通路图（11张）

Efg signaling pathway



HER1 and HER2 signaling pathway:A broader inhibition of HER family receptors may be necessary to inhibit multiple pathways in HER2–driven breast cancer



egfr inhibition



EGFR signaling pathway2



EGFR_signaling_pathway



HER signaling pathway:The epidermal growth factor receptor (EGFR) is one of four receptors in the HER (human epidermal growth factor receptor) signaling pathway. The pathway consists of at least four Cell ular receptors: EGFR/HER1, HER2, HER3, and HER4. Approximately 11 different factors are known to bind and activate these receptors in certain patterns. The HER signaling pathway plays a role in the normal regulation of cell growth, proliferation, migration, and mediating processes, such as wound healing, tissue repair, and maintenance of the skin. In addition to its role in controlling the growth of normal cells, the HER signaling pathway has been shown to have a significant impact on the growth, proliferation, migration, and survival of cancer cells.



HER2 and HER3



Role of ERBB2 in Signal Transduction and Oncology:Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the molecular weight of 185 KDa. Unlike other members of EGFR family, no ligand for Her2 has been found and it usually associates with members of ERBB1 family to form functional heterodimers. It has been shown that it can form dimers with ERBB (EGFR), ERBB3 and ERBB4 as well as gp130 subunits of IL-6 receptor. In at least some cell types, the association between gp130 and HRBB2 is essential for HRBB2-ERBB3 phosphorylation and subsequent MAP kinase signaling. Although ERBB1 can form homodimers, the signaling for ERBB1 is usually transient and the receptor undergoes internalization after ligand binding and activation. EGFR-HER2 complex increases the signaling capacity of EGFR by increasing the ligand affinity as well as the recycling of the heterodimer. Of all the ERBB heterodimers, ERBB2-ERBB3 heterodimers perhaps elicit the strongest signal. Removing ERBB3 from the cell has a drastic effect on ERBB2 mediated signaling and downstream effectors.



the HER signaling pathway



Vegfr 2 signaling pathway



VEGF介导的血管生成和缺氧途径