Diagnostic Applications of Protein Microarrays

The sequencing of the human genome has opened the door for proteomics by providing a sequence-based framework to mine the human proteome. Although the field of proteomics was initially dominated by two-dimensional gels and mass spectrometry, the current emphasis is on developing proteome-scale high-throughput methods, as exemplified by the development of protein microarrays. This chapter addesses the utility of protein microarrays for clinical applications. Additional information about protein microarrays can be found in several review articles that have been published in various journals (1 –4 ).