Oligonucleotide Analogs Containing Dephospho-Internucleoside Linkages
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Nonionic oligonucleotide analogs have attracted much interest in recent years as potential candidates for oligonucleotide-based therapeutics. Compared to their natural parent molecules, they are expected to have the advantage of:
1. | Being stable against degrading nucleases, |
2. | Showing enhanced cellular uptake, and |
3. | Having the ability to form more stable complexes with complementary sequences owing to reduced charge repulsion. |