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Oligonucleotide Analogs Containing Dephospho-Internucleoside Linkages

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526
Nonionic oligonucleotide analogs have attracted much interest in recent years as potential candidates for oligonucleotide-based therapeutics. Compared to their natural parent molecules, they are expected to have the advantage of:
1.  Being stable against degrading nucleases,
2.  Showing enhanced cellular uptake, and
3.  Having the ability to form more stable complexes with complementary sequences owing to reduced charge repulsion.
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