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Testing Meningococcal Vaccines for Mitogenicity and Superantigenicity

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Proteins with intrinsic mitogenic properties are widely represented in prokaryotes, such as in different Streptococcus species (1 3 ), Candida albicans (4 ), and Eikenella corrodens (5 ). Specifically, several bacterial porins of Escherichia coli, Shigella dysenteriae, Salmonella typhimurium, Fusobacterium nucleatum , and pathogenic Neisseria species have been shown to induce nonspecific proliferation of lymphocytes (6 12 ).
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