Surface Plasmon Resonance Biosensing
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Surface plasmon resonance (SPR) biosensors belong to label-free optical biosensing technologies. The SPR method is based on
optical measurement of refractive index changes associated with the binding of analyte molecules in a sample to biorecognize
molecules immobilized on the SPR sensor. Since late 1990's, SPR biosensors have become the main tool for the study of biomolecular
interactions both in life science and pharmaceutical research. In addition, they have been increasingly applied in the detection
of chemical and biological substances in important areas such as medical diagnostics, environmental monitoring, food safety
and security. This chapter reviews the main principles of SPR biosensor technology and discusses applications of this technology
for rapid, sensitive and specific detection of chemical and biological analytes.
