CD42a/CD42b/CD42c/CD42d分子
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CD42a/CD42b/CD42c/CD42d 分子
CD42a
常用单克隆抗体或代号： FMC25,GR- P;(GPIX)
主要表达细胞： Pt,Meg [Pt]
分子质量(kDa)和结构： gp22,形成血小板,GPIb/Ⅸ复合物功 能： 血小板粘附,结合vWF、凝血酶
CD42b
常用单克隆抗体或代号： PHN89,AN51;(GPIba )
主要表达细胞： Pt,Meg [Pt]
分子质量(kDa)和结构： gp135,血小板GPIb- a ,形成GPIb/Ⅸ复合物
功 能： 血小板粘附,结合vWF
CD42c
常用单克隆抗体或代号： (GPIbb )
主要表达细胞： Pt,Meg [Pt]
分子质量(kDa)和结构： gp22,血小板GPIb- b
功 能： 血小板粘附,结合vWF
CD42d
常用单克隆抗体或代号： (GPIb- IX- V复合物）
分子质量(kDa)和结构： Pt,Meg [Pt]
分子质量(kDa)和结构： gp85,血小板GPV
功 能： 血小板粘附,结合vWF
CD42a
Aka platelet GPIX
CD42a-d complex is receptor for von Willebrand factor and thrombin
Actual binding site of vWf and thrombin is on CD42b
This complex mediates adhesion of platelets to subendothelial matrices exposed upon damage to endothelium and amplifies platelet response to thrombin
Absence of CD42 complex (mutations in CD42 a-c) causes Bernard-Soulier syndrome (BSS), a bleeding disorder with thrombocyenia and giant platelets
Positive staining (normal): platelets and megakaryocytes
CD42b
Aka platelet GPIb alpha
CD42a-d complex is receptor for von Willebrand factor and thrombin
Actual binding site of vWf and thrombin is on CD42b
Positive staining (normal): platelets and megakaryocytes
Positive staining (disease): blasts in transient myeloproliferative disorder
CD42c
Aka platelet GPIb beta
Positive staining (normal): platelets and megakaryocytes
CD42d
Aka platelet GP V
CD42d mouse monoclonal antibodies are used to detect auto- and allo-anti-platelet antibodies
Co-expression studies suggest that CD42d may be essential to form the high affinity thrombin receptor
Positive staining (normal): platelets and megakaryocytes
