Intra-epidermal Nerve Fibers Density and Nociception in EPO-Treated Type 1 Diabetic Rats with Peripheral Neuropathy
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Small-diameter nerve fibers, which subserve nociception, can be affected early in peripheral neuropathies, although their
injury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliable
tool to examine nonmyelinated nerve fibers, as assessed by the quantification of intra-epidermal nerve fiber (IENF) density
not only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacy
such as erythropoietin (EPO) treatment.
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