【讨论】genome tiling

全基因组瓦片芯片（whole-genome tiling array）谁用过，给大家讲讲。
8D

有谁了解这个技术的发展历史和特点、用途的吗？
http://en.wikipedia.org/wiki/Tiling_array

Whole genome tiling arrays (WGA) use array-based hybridyzation to scan the entire genome of an organism. This is achieved by using a set of overlapping oligonucleotide probes representing the whole genome. This new technology has many applications, such as novel gene discovery, gene expression studies, and discovery of transcription binding sites. WGAs are available for Arabidopsis thaliana and E.coli, and other WGAs, namely yeast and human, are under development. Through use in model organisms and then in humans WGAs will likely be a powerful new tool in biomedical research.

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.129.101&rep=rep1&type=pdf.

基于重叠延伸的杂交原理。
个人觉的这种芯片只是昙花一现。出现也没几年，但应该很快被越来越便宜的测序技术所更新替代。