【资源】Protein Degradation: Ubiquitin and the Chemistry of Life

Publisher: Wiley-VCH
Number Of Pages: 393
Publication Date: 2005-05-06
Sales Rank: 1682711
ISBN / ASIN: 3527308377
EAN: 9783527308378
Binding: Hardcover
Manufacturer: Wiley-VCH
Studio: Wiley-VCH
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Book Description:

The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway.

The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series,
and Avram Hershko has contributed to the opening chapter of the present volume.

Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes.

Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.

Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

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