Animal Models of Acute Surgical Pain
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Animal models of tissue injury have been used to investigate the mechanisms of pain. Here, we describe a variety of animal
models that have been used to mimic acute surgical pain in human subjects, which include the plantar, tail, and gastrocnemius
incision models. We also provide discussion on animal models of laparotomy, thoracotomy, visceral pain, and bone injury. Preclinical
studies using these models have provided insights into the mechanisms and causes of acute surgical pain as well as the treatment
options to control postsurgical pain.
