Production of Bispecif ic and Trispecific F(ab)2 and F(ab)3 Antibody Derivatives
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Bispecific antibodies (BsAbs) are hybrid molecules designed to combine two antibodies with different specificities. This dual specificity has led to their application in a variety of diagnostic situations that require the crosslinking of two protein surfaces, for example, antigen and detecting agent in lmmunohis-tochemistry or immunoassays. More interestingly, BsAbs have been shown to have considerable therapeutic potential when used as targeting reagents to deliver pharmacological substances (drugs or toxins) or cellular effectors (T-cells, monocytes, or NK cells) to tumor cells (1 ,2 ). A relatively new development is the design of BsAbs to deliver chelated radiometals for the diagnostic imaging of tumors and for radioimmunotherapy (1 ).