CD56分子

CD56

Aka N-CAM (neural cell adhesion molecule), at #11q23

Regulates homophilic (like-like) interactions between neurons and between neurons and muscle

Also associates with fibroblast growth factor receptor and stimulates tyrosine kinase activity of receptor to induce neurite outgrowth

When neural crest cells s making N-CAM and N-cadherin and start displaying integrin receptors, cells separate and migrate

Contributes to cell-cell or cell-matrix adhesion during development

Lymphocyte activated killer phenomenon mediated by IL-2 activated CD56+, CD3-, NK cells

Prototypic marker of NK cells, also present on subset of CD4+ and CD8+ T cells

Positive staining (normal): NK cells (80-90%), activated T cells; cerebellum and brain at neuromuscular junctions, also normal neuroendocrine tissues

Positive staining (tumors): myeloma, myeloid leukemia, neuroendocrine tumors, Wilm’s tumor, adult neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, small cell lung carcinoma

Negative staining: PNET/Ewing’s sarcoma

Micro images: testicular NK/T cell lymphoma (figure 3C), extranodal NK/T cell lymphoma, nasal type