CD62E/CD62L/CD62P分子
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CD62E/CD62L/CD62P 分子
CD62E
常用单克隆抗体或代号： 3B7,4D1O;(E- selectin,ELAM- 1)
主要表达细胞： En [AS]
分子质量(kDa)和结构： gp110(C- lectin SF)结合白细胞ELS- 1
功 能： 粘附L- selectin,中性粒细胞通过结合CD15s结合到En
CD62L
常用单克隆抗体或代号： Leu8,FMC46;(L- selectin,LAM- 1,LECAM- 1)
主要表达细胞： T,B,M,NK,PMN,Eo[AS]
分子质量(kDa)和结构： gp76(C- lectin SF,含EGF样结构域和2个CCP结构域)
功 能： 粘附CD15s、E- selectin,P- selectin,结合Gly- CAM- 1、CD34、MAd- CAM- 1上的O连接糖
CD62P
常用单克隆抗体或代号： G2,AK- 6;(P- selectin,GMP- 140,PADGEM)
主要表达细胞： Pt,Meg,Enac [Pt]
分子质量(kDa)和结构： gp140,血小板a 颗粒(C- lectin SF)
功 能： 结合PMN、M表面CD15s、CD15、CD24、CD162(PSGL- 1)粘附到En和Pt
CD62E
Aka E selectin; endothelial leukocyte adhesion molecule-1 (ELAM-1)
Ligand for sialyl-Lewis X
Mediates leukocyte rolling on activated endothelium at inflammatory sites, atherosclerosis, tumor cell adhesion during hematogenous metastasis
Patients with Leukocyte Adhesion Deficiency 2 syndrome, who lack sialyl Lewis X component of selectin counter-receptors, suffer recurrent pyogenic infections
Positive staining (normal): endothelial cells (after cytokine stimulation)
CD62L
Aka L selectin; LECAM-1
Mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue, leukocyte rolling on activated endothelium at inflammatory sites
Positive staining (normal): B, T, NK cells, monocytes, neutrophils, eosinophils, precursors
Reference: 153240
CD62P
Aka P selectin; PADGEM
Interaction with CD162 mediates tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration
Mediates rolling of platelets on endothelial cells, platelet-mediated delivery of lymphocytes to high endothelial venules
Constitutive expression in inflammation may contribute to tissue destruction, atherogenesis and thrombosis
May be reduced in gray platelet syndrome, 139090
Redistributes to the plasma membrane during platelet activation and degranulation.
Positive staining (normal): platelets, megakaryocytes, activated endothelial cells
