[3H]-GABA Binding to GABAA and GABAB Sites on Rat Brain Crude Synaptic Membranes
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GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the central nervous system and acts on three pharmacologically distinct receptors: GABAA , GABAB , and GABAC . GABAA receptors are pharmacologically defined on the basis of antagonism by bicuculline and insensitivity to the GABA-analog baclofen, whereas GABAB receptors are stimulated by baclofen and are insensitive to bicuculline; GABAC receptors are insensitive to both (1 ).