Measuring Rodent Electroretinograms to Assess Retinal Function

Electroretinography is a noninvasive technique used to measure the electrical activity of neurons in the retina. Electroretinogram (ERG) waveforms can be used to quantify retinal function in normal and diseased rodents. In particular, the functions of rod and cone pathways can be isolated. Inner retinal neuronal functioning, such as bipolar cell activity or ganglion cell activity, can also be measured. In this chapter we describe the common full-field ERG techniques of scoptic flash, photopic flash, and flicker used to isolate and compare rod-driven and cone-driven function.