CD15/CD15s/CD15u分子
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1920
CD15/CD15s/CD15u 分子
CD15
常用单克隆抗体或代号: MY1,LeuM1
主要表达细胞: G,(M),RS [AS]
分子质量(kDa)和结构: Lewisx3FAL,X- hapten
功 能: 参与中性粒细胞粘附和吞噬
CD15s
常用单克隆抗体或代号: (唾液酸化CDl5)
主要表达细胞: G,M [AS]
分子质量(kDa)和结构: Sialyl Lewisx(sLex)
功 能: CD62E、CD62L、CD62P配体,白细胞粘附到En和Pt
CDl5u
常用单克隆抗体或代号: (硫酸化CDl5)
主要表达细胞: T,NK,En,G,M[CHol
功 能: 参与碳水化合物介导的细胞黏附
CD15
Aka LeuM1, Lacto-N-Fucopentose III ceramide
Recognizes Hapten X, a carbohydrate linked to cell membrane proteins of myelomonocytic cells
Positive staining (normal): myeloid cells (90%); activated B and T cells (including infectious mononucleosis); eosinophils stain intensely
Positive staining (disease): Reed-Sternberg cells, 20% of T cell lymphomas, 5% of B cell lymphomas, 50% of carcinomas
Negative staining: erythroid cells, platelets; ALL
Micro images: Reed-Sternberg cells-figure 3A, primary pulmonary Hodgkin’s lymphoma-figure 3A
CD15s
Aka Sialyl Lewis X; ligand for CD62P and CD62E
Positive staining (normal): granulocytes, macrophages
CD15u
Aka sulfated CD15