【资源】酶学类电子书

1.Computer Modeling of Chemical Reactions in Enzymes and Solutions (Wiley Professional)
Author: Arieh Warshel
Publisher: Wiley-Interscience
Publication Date: 1997-03-01
Number Of Pages: 256

This practical reference explores computer modeling of enzyme reations--techniques that help chemists, biochemists and pharmaceutical researchers understand drug and enzyme action

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2.Computer Modeling of Chemical Reactions in Enzymes and Solutions
Author: Arieh Warshel
Publisher: Wiley-Interscience
Publication Date: 1991-11
Number Of Pages: 236

This practical reference explores computer modeling of enzyme reations--techniques that help chemists, biochemists and pharmaceutical researchers understand drug and enzyme action.

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3.Enzymes and Their Inhibitors: Drug Development
Author: H. John Smith (Editor), Claire Simons (Editor)
Publisher: CRC
Publication Date: 2004-07-15
Number Of Pages: 328

Summary:

Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibition provides an overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, substrates, kinetics, and mechanisms of enzymes. Subsequent chapters discuss various types of enzyme inhibitors and the principles involved in developing them into effective drugs. This book describes the problems that can be encountered in translating results from the bench to the market place, and suggests approaches that circumvent these difficulties. This outstanding text for students in pharmacology and medicinal chemistry is also a valuable professional reference.
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4.Enzymes in the Environment (Books in Soils, Plants, and the Environment)
Author: Burns R.G., Dick R.P.
Publisher: CRC
Publication Date: 2002-01-15
Number Of Pages: 640

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The need to understand the biological processes that are important for essential aquatic and terrestrial ecosystem function has prompted much research into the field of ecological enzymology. This book presents the two broad areas of application in a compilation of reviews by 21 international experts in their respective fields. The first explores enzymatic activities to assess the processes or mechanisms that operate in a given system, such as the rhizosphere, plant leaves and shoots, soil surfaces, and biofilms. The second considers enzymes or microbial cells as sensors to detect microbial activity and stresses due to pollution, management, or climatic change in both aquatic and terrestrial ecosystems.

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5.Enzymes of Molecular Biology (Methods in Molecular Biology (Clifton, N.J.), 16.)
Author:
Publisher: Humana Press
Publication Date:
Number Of Pages: 370

Provides key information on a wide range of enzymes commonly used as tools in molecular biology, helping to minimize the time a scientist spends researching the literature to get reactions to work efficiently and allowing the nonenzymologist to design an experiment. Each chapter gives background information on the enzyme selected and those parameters important in its use, describes both the source and application of the enzyme, and provides details on the size and structure of the protein. Specific parameters essential for achieving an optimized reaction are discussed, along with exemplary practical procedures an protocols.

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6.Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis
Author: Robert A. Copeland
Publisher: Wiley-VCH
Publication Date:
Number Of Pages: 397

Fully updated and expanded-a solid foundation for understanding experimental enzymology. This practical, up-to-date survey is designed for a broad spectrum of biological and chemical scientists who are beginning to delve into modern enzymology. Enzymes, Second Edition explains the structural complexities of proteins and enzymes and the mechanisms by which enzymes perform their catalytic functions. The book provides illustrative examples from the contemporary literature to guide the reader through concepts and data analysis procedures. Clear, well-written descrīptions simplify the complex mathematical treatment of enzyme kinetic data, and numerous citations at the end of each chapter enable the reader to access the primary literature and more in-depth treatments of specific topics. This Second Edition of Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis features refined and expanded coverage of many concepts, while retaining the introductory nature of the book. Important new features include: * A new chapter on protein-ligand binding equilibria * Expanded coverage of chemical mechanisms in enzyme catalysis and experimental measurements of enzyme activity * Updated and refined discussions of enzyme inhibitors and multiple substrate reactions * Coverage of current practical applications to the study of enzymology Supplemented with appendices providing contact information for suppliers of reagents and equipment for enzyme studies, as well as a survey of useful Internet sites and computer software for enzymatic data analysis, Enzymes, Second Edition is the ultimate practical guide for scientists and students in biochemical, pharmaceutical, biotechnical, medicinal, and agricultural/food-related research

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7.Directed Molecular Evolution of Proteins : or How to Improve Enzymes for Biocatalysis
Author: Susanne Brakmann (Editor), Kai Johnsson
Publisher: Wiley-VCH
Publication Date: 2002-05-06
Number Of Pages: 368

Natural selection created optimal catalysts. However, optimal performance of enzyme catalysis does not necessarily refer to maximum reaction rate. Rather, it may be a compromise between specificity, rate, stability, and other chemical constraints that makes enzymes capable of catalyzing reactions under mild conditions and with high substrate specificity, accompanied by high regio- and enantioselectivity. The book presented here focuses on the directed evolution of proteins, which has established itself as a powerful method for designing enzymes showing new substrate specificities. It includes a comprehensive repertoire of techniques for producing combinatorial enzyme libraries, while the functional gene expression in a suitable host helps in selecting the appropriate structure, making fast screening a necessity. This book illustrates both the theoretical background as well as the potential of this interesting method in practice - which is becoming ever more important even in classical organic synthesis!

Book Info
Universitat Leipzig, Germany. Focuses on the directed evolution of proteins and the methods for designing enzymes showing new substrate specialties. Includes a comprehensive listing of techniques, illustrates the theoretical background, and the potential of methods in practice. Contains halftone illustrations and diagrams. Written in expanded-outline format.

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8.Biochemical catalysts in life and industry;: Proteolytic enzymes,
Author: Jean Effront
Publisher: John Wiley & Sons;
Publication Date: 1917
Number Of Pages: 752
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9.Comprehensive Enzyme Kinetics
Author: Vladimir Leskovac
Publisher: Plenum US
Publication Date: 2003-03
Number Of Pages: 442

Descrīption
This text for advanced courses in enzyme chemistry and enzyme kinetics covers the field of steady-state enzyme kinetics from the basic principles inherent in the Michaelis-Menten equation to expressions that describe the multi-substrate enzyme reactions, providing a framework for the study of enzymes with the aid of kinetic studies of enzyme-catalyzed reactions. Discussion encompasses chemical kinetics, kinetics of monosubstrate reactions, and cooperative and allosteric effects

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10.Enzyme Kinetics : A Modern Approach
Author: Alejandro G. Marangoni
Publisher: Wiley-Interscience
Publication Date: 2002-11-15
Number Of Pages: 248
Practical Enzyme Kinetics provides a practical how-to guide for beginning students, technicians, and non-specialists for evaluating enzyme kinetics using common software packages to perform easy enzymatic analyses

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11.Structure and Mechanism in Protein Science : A Guide to Enzyme Catalysis and Protein Folding
Author: Alan Fersht
Publisher: W. H. Freeman
Publication Date: 1999-01
Number Of Pages: 631

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12.Enzyme Systems that Metabolise Drugs and Other Xenobiotics (Current Toxicology)
Author: Costas Ioannides (Editor)
Publisher: John Wiley & Sons 2002
Publication Date: 2002-01-28
Number Of Pages: 588

This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:
enzyme function in the metabolism and bioactivation of xenobiotics
substrate specificity
tissue distribution
species distribution (to include laboratory animals and humans)
hormonal regulation
sex differences
modulation by prior exposure to other chemicals
age-dependent expression
pharmacogenetics and modulation by disease.
Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.

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