【求助】SB202190和SB203580？

想请教大虾们一个问题，我准备定p38mapk的磷酸化抑制剂，看有SB202190和SB203580两种，文献上都有用，但是不知道有什么区别，该如何选择？
还有从哪家公司购买比较好？calbiochem?

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去丁香通发布你的“求购信息”
我想找（买）……

丁香通客服

?我不是求购呀，主要是想问问战友们这两种抑制剂有什么区别......

对SB203580的描述：A highly specific, cell-permeable inhibitor of p38 kinase (IC50 = 34 nM in vitro, 600 nM in cells). Also known as reactivating kinase (RK) and CSBP (cytokine synthesis anti-inflammatory drug binding protein). Does not significantly inhibit JNK or p42 MAP kinase even at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). SB 203580 has also been shown to be an effective inhibitor of inflammatory cytokine production in vivo in both mice and rats.
对SB202190的描述：A potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (Ki = 16 nM; IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells.
我想来了应该明白了，我是merck的代理商，要买的话可以跟我联系

SB 202190：SB202190 blocked p38 half maximally at 30 nM. Concentrations as high as 30,000 nM did not inhibit ERK and JNK activity.作用效果如下：


SB 203580：SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM). 作用效果如下：