求助，这个稿件修改要求该怎么改比较好

尤其是第四点，写的动物实验的论文，求大神指导一下

4.Another obvious problem with this paper is lack of sufficient explanation of the simulation results. You need to explain your simulation results in detail and why you got such results.And the relationship between the result index and the mechanism.

5.CONCLUSIONS needs more in it, as it's more of an afterthought. The authors are suggested to highlight important findings and include afterthought of this work.

6.The significance of this paper is not expound sufficiently. The author need to highlight this paper's innovative contributions.