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丁香实验推荐阅读
Gadolinium-Loaded Polychelating Polymer-Containing Tumor-Targeted Liposomes

Magnetic resonance (MR) is one of the most widely used imaging modalities in contemporary medicine to obtain images of pathological areas. Still, there is a big effort to facilitate the accumulation of contrast in the required zone and further increase a local spatial concentration of a contr ...

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Angiogenic Vessel-Targeting DDS by Liposomalized Oligopeptides

Liposomal oligopeptides are one of the promising nanocarriers to deliver a drug, DNA or siRNA to target tissues. In this chapter, we describe our methodology to develop liposomal oligopeptides targeting to tumor angiogenic vessels. At first, we introduce our strategies to identify obje ...

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TAT-Peptide Modified Liposomes: Preparation, Characterization, and Cellular Interaction

In general, cellular internalization of macromolecular drugs encapsulated in liposomes proceeds via endocytosis. This potentially leads to degradation of the liposome-encapsulated macromolecular content within the endosomal/lysosomal compartment. Therefore, b ...

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ATP-Loaded Liposomes for Targeted Treatment in Models of Myocardial Ischemia

ATP cannot be effectively delivered to most tissues including the ischemic myocardium without protection from degradation by plasma endonucleotidases. However, it has been established that ATP can be delivered to various tissues by its encapsulation within liposomal preparat ...

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Intracellular ATP Delivery Using Highly Fusogenic Liposomes

Healthy cells must maintain a high content of adenosine triphosphate (ATP) because almost all energy-requiring processes in cells are driven, either directly or indirectly, by hydrolysis of ATP. During ischemia or hypoxia, reduced blood flow or disturbed oxygen supply results in the dis ...

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Lipoplex Formation Using Liposomes Prepared by Ethanol Injection

Cationic liposomes composed of 3β- cholesterol (DC–Chol) and dioleoylphosphatidylethanolamine (DOPE) (DC–Chol/DOPE liposome, molar ratio, 1:1 or 3:2) prepared by the dry-film method have been often used as non-viral gene delivery vectors. We have shown that a more efficient transfec ...

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Serum-Resistant Lipoplexes in the Presence of Asialofetuin

Vectors proposed for gene delivery generally fall into two categories: viral and nonviral. They differ primarily in their assembling process. A viral vector is assembled in a cell, whereas a nonviral vector is constructed in a test tube. While vectors based on viral-based delivery systems are r ...

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Acid-Labile Liposome/pDNA Complexes

One of the bottlenecks to achieve gene or drug delivery to cells is the spatio-temporal release of the cargo to effect the correct task whereever and whenever it is supposed to. The aim of this chapter is to describe the synthesis and properties of lipids, which can form liposome complexes with DNA and to fa ...

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Nanoliposomes: Preparation and Analysis

Nanoliposome, or submicron bilayer lipid vesicle, is a new technology for the encapsulation and delivery of bioactive agents. The list of bioactive material that can be incorporated to nanoliposomes is immense, ranging from pharmaceuticals to cosmetics and nutraceuticals. Becau ...

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Anionic pH Sensitive Lipoplexes

To provide long circulating nanoparticles which can carry a gene to tumors, we have designed anionic pegylated lipoplexes that are pH sensitive. Anionic pegylated lipoplexes have been prepared from the combined formulation of cationic lipoplexes and pegylated anionic liposomes. ...

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Complexation of siRNA and pDNA with Cationic Liposomes: The Important Aspects in Lipoplex Preparation

In the last two decades, cationic liposomes have been investigated as vehicles for nucleic acids delivery in vitro and in vivo. The formation of cationic liposomes–nucleic acids complexes, termed lipoplexes, depends on a number of experimental variables. The quality of the nucleic acid and ...

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Liposomal siRNA Delivery

With the recent discovery of small interfering RNA (siRNA), to silence the expression of genes in vitro and in vivo, there has been a need to deliver these molecules to the cell nucleus. Forming a lipid/nucleic acid complex has become a solution and is explored here. Certain methods and ideas are used, such ...

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Effective In Vitro and In Vivo Gene Delivery by the Combination of Liposomal Bubbles (Bubble Liposomes) and Ultrasound Exposure

Gene delivery with a physical mechanism using ultrasound (US) and nano/microbubbles is expected as an ideal system in terms of delivering plasmid DNA noninvasively into a specific target site. We developed novel liposomal bubbles (Bubble liposomes (BLs)) containing the lipid nanobu ...

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Liposomal Magnetofection

In a magnetofection procedure, self-assembling complexes of enhancers like cationic lipids with plasmid DNA or small interfering RNA (siRNA) are associated with magnetic nanoparticles and are then concentrated at the surface of cultured cells by applying a permanent inhomogene ...

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Long-Circulating, pH-Sensitive Liposomes

A major limiting factor for the wide application of pH-sensitive liposomes is their recognition and sequestration by the phagocytes of the reticulo-endothelial system, which conditions a very shortcirculation half-life. Typically prolonged circulation of liposomes is achi ...

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Preparation of DRV Liposomes

Dried reconstituted vesicles (DRV) are liposomes that are formulated under mild conditions and have the capability to entrap substantially high amounts of hydrophilic solutes (compared with other types of liposomes). These characteristics make this liposome type ideal for entr ...

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Serum-Stable, Long-Circulating, pH-Sensitive PEGylated Liposomes

pH-sensitive liposomes have been designed to deliver active compounds, specifically to acidic intracellular organelles and to augment their cytoplasmic concentrations. These systems combine the protective effects of other liposomal formulations with specific enviro ...

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Elastic Liposomes for Topical and Transdermal Drug Delivery

Elastic liposomes have been developed and evaluated as novel topical and transdermal delivery systems. They are similar to conventional liposomes but with the incorporation of an edge activator in the lipid bilayer structure to provide elasticity. Elastic liposomes are applied non ...

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Archaebacterial Tetraetherlipid Liposomes

Liposomes are widely investigated for their applicability as drug delivery systems. However, the unstable liposomal constitution is one of the greatest limitations, because the liposomes undergo fast elimination after application to the human body. In the presented study, novel a ...

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Cationic Magnetoliposomes

Magnetoliposomes (MLs) consist of nanosized, magnetisable iron oxide cores (magnetite, Fe3O4) which are individually enveloped by a bilayer of phospholipid molecules. To generate these structures, the so-called water-compatible magnetic fluid is first synthesized by co-pr ...

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