PC/GENE: Translation and Searches for Protein Coding Regions

Translation of a nucleic acid sequence into a polypeptide sequence is required in a variety of situations. For example, when performing a DNA sequencing project, one frequently will translate the sequence in order to search for open reading frames. If open reading frames are found, it is desirable to know the probability that they in fact code for protein. Another situation requiring translation of a nucleic acid sequence is when a sequence is retrieved from a data base and the corresponding protein sequence is required for further analysis, for example, alignment with other proteins. PC/GENE contains several programs that make these operations easy to carry out.