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Preparation and Preclinical Characterization of RNase-Based Immunofusion Proteins

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Toxins from plants and bacteria have been coupled to antibodies to produce selective cytotoxic agents (immunotoxins) (1 3 ). However, toxic side effects and immunogenicity have presented major obstacles to the successful clinical application of these proteins (4 9 ). Production of humanized antibodies has alleviated the immunogenicity of the targeting component (10 ). Substituting plant and bacterial toxins with members of the pancreatic RNase A superfamily (for review see ref. 11 ) presents a solution to problems associated with the effector portion of immunotoxins (12 ).
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