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Protein Structure,Stability, and Folding
Edited by
Kenneth P. Murphy
University of Iowa College of Medicine, Iowa City, IA
© 2001 Humana Press Inc.
999 Riverview Drive, Suite 208
Totowa, New Jersey 07512
下载目录在 /基础医学区/蛋白质技术专业组/pub/
Preface
In 1995, Humana Press published a book edited by Dr. Bret A. Shirley
entitled Protein Stability and Folding: Theory and Practice. This book detailed
the use of many of the most important techniques for studying the stability and
folding of proteins, but emphasized the Practice more than the Theory. The current
volume, Protein Structure, Stability, and Folding, is a companion to the
earlier work. In this volume more emphasis is placed on the Theory, although
chapters on exciting new experimental approaches are included. Together, the
two volumes cover a broad range of experimental and computational approaches
to studying and understanding protein structure, stability, and folding.
Since the publication of Shirley's work, there have been many exciting
advances in both theory and experiment. Advances in the power of theoretical
approaches now make it feasible to calculate many aspects of protein stability
and dynamics from knowledge of the structure. The present book, Protein
Structure, Stability, and Folding includes chapters on these calculations, as
well as approaches for calculating conformational entropy and performing
molecular dynamics simulations of protein unfolding. New experimental
approaches are also being used to look at stability and folding. These include
the use of co-solvents, new applications of hydrogen exchange techniques,
temperature-jump methods for looking at fast folding events, and new strategies
for mutagenesis experiments.
I would like to thank all the authors who contributed to this book for their
hard work and extraordinary patience. I would also like to thank my colleagues
in the Department of Biochemistry and especially the members of my laboratory
for their encouragement in this project. Finally I would like to thank my
wife, Lee, and my children, Kevin, Katie, and Ellen, whose love and faith
make it all worthwhile.
Kenneth P. Murphy
Protein Structure,Stability, and Folding
Edited by
Kenneth P. Murphy
University of Iowa College of Medicine, Iowa City, IA
© 2001 Humana Press Inc.
999 Riverview Drive, Suite 208
Totowa, New Jersey 07512
下载目录在 /基础医学区/蛋白质技术专业组/pub/
Preface
In 1995, Humana Press published a book edited by Dr. Bret A. Shirley
entitled Protein Stability and Folding: Theory and Practice. This book detailed
the use of many of the most important techniques for studying the stability and
folding of proteins, but emphasized the Practice more than the Theory. The current
volume, Protein Structure, Stability, and Folding, is a companion to the
earlier work. In this volume more emphasis is placed on the Theory, although
chapters on exciting new experimental approaches are included. Together, the
two volumes cover a broad range of experimental and computational approaches
to studying and understanding protein structure, stability, and folding.
Since the publication of Shirley's work, there have been many exciting
advances in both theory and experiment. Advances in the power of theoretical
approaches now make it feasible to calculate many aspects of protein stability
and dynamics from knowledge of the structure. The present book, Protein
Structure, Stability, and Folding includes chapters on these calculations, as
well as approaches for calculating conformational entropy and performing
molecular dynamics simulations of protein unfolding. New experimental
approaches are also being used to look at stability and folding. These include
the use of co-solvents, new applications of hydrogen exchange techniques,
temperature-jump methods for looking at fast folding events, and new strategies
for mutagenesis experiments.
I would like to thank all the authors who contributed to this book for their
hard work and extraordinary patience. I would also like to thank my colleagues
in the Department of Biochemistry and especially the members of my laboratory
for their encouragement in this project. Finally I would like to thank my
wife, Lee, and my children, Kevin, Katie, and Ellen, whose love and faith
make it all worthwhile.
Kenneth P. Murphy
