Atomic Force Microscopy of Protein Complexes

Scanning probe microscopy (SPM) is a rather new family of surface studies methods, having broad applications to biomedical science. The main advantage of SPM over conventional microscopic techniques (i.e., scanning and transmission electron microscopy) is its ability to study living objects in their natural environment and, therefore, the ability to observe dynamical processes occurring to them with subnanometer resolution. Here, we will discuss one of its family members, atomic force microscopy (AFM), which has yielded fascinating results for the past decade.