Molecular Analysis in Factor XI Deficiency
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Factor XI (FXI) is the zymogen precursor of an active serine protease that participates in the contact phase of coagulation. Synthesized in the liver, it circulates in the plasma in a noncovalent complex with high molecular weight kininogen (1 ) at a normal concentration of 5 μg/mL. (For clinical purposes, the normal range is defined as 50–150 U/dL) (2 ). FXI circulates as a homodimeric glycoprotein with a mass of 160 kDa.
