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The Pathway of miRNA Maturation

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406
MicroRNAs (miRNAs) are a novel class of 17–23 nucleotide short, nonprotein-coding RNA molecules which have emerged to be key players in posttranscriptional gene regulation. In this chapter we give an in-depth review of the classic, canonical mammalian miRNA maturation pathway and discuss new, noncanonical alternatives such as the mirtron pathway which were recently described.
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