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Naming mouse strains

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Naming mouse strains

There are internationally accepted rules to name transgenic and knock-out mice. See the following links:

Mouse Nomenclature Rules and Guidelines

These are suggestions about how to name mice, following the above quoted rules:
 

Transgenic mice:
 
promoter and gene combined acronymmutation - founder# - mouse#
 example: lckB6 -16 -123
 example: eµSVIRTA2tm -2 -65


Breeding of two transgenic strains will be:

promoter and gene combined acronymsmutation - mouse#
 example: CD19Cre-CMVHAB6lox -8


The promoter and gene names may be combined in order to have a very short, but explicative 4-6 letter heading
Strain has been omitted, because most of the mice used are outbred. Inbred lines may be indicated after the founder with an i   for inbred.
mice are numbered sequentially as they are born. A progressive numbering is used for each line. This will allow toe identification of mice, and an unique number for each mouse in the line.

Knock-out mice (Targeted mutations):
 
 genemutation - ES cell clone - mouse#
example: B6D -T1/8-28


Transgenic and KO breeding:
 

KO nameTG acronymmutation - mouse#
 example: p53null -lckB6 -123
 example: B6D -MD4 -65


Individual mice will be reported as

Transgenics:
TG or TG/- or TG/TG when transgenics
Knock-out:
+/+ or +/- or -/-
+/+, +/D and D/D

 

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